Abstract
Therapeutic advances have resulted in increased life expectancy in patients with hemophilia. Consequently, the prevalence of coronary artery disease in this population is increasing. Little is known about the optimal management of acute coronary syndrome in these patients. Current guidelines for the management of this condition are based mainly on expert opinion and generally recommend administration of the clotting factor prior to the anticoagulant, antiplatelet, and interventional therapies. We report a case that illustrates the potential harm that may come from this approach: evolution of non–ST-segment elevation acute coronary syndrome into ST-elevation acute coronary syndrome during the administration of recombinant clotting factor. We review available literature and describe the refined informatics-based guidelines for managing acute coronary syndrome in patients with hemophilia we developed in response to the presented clinical case. We propose adopting this novel informatics-based approach, which aids in the identification and early treatment of these patients, operationalizes timely involvement of hematology experts, and gathers data for further study.
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Koki Nishimura MD was a co-author of this manuscript. However, we are unable to reach him.
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Dr. Leavitt reports having served on the Medical Advisory Boards for BioMarin, CSL, and Genentech.
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Supplementary Information 1—UCSF joint cardiology and hematology clinical practice guideline foracute coronary syndromes in patients with hemophilia (PDF 114 KB)
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Mayfield, J.J., Leavitt, A.D., Tanriverdi, T. et al. Acute coronary syndrome in patients with hemophilia: a delicate balancing act. J Thromb Thrombolysis 54, 323–329 (2022). https://doi.org/10.1007/s11239-022-02664-y
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DOI: https://doi.org/10.1007/s11239-022-02664-y